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Expression of Utrophin at Dystrophin‐Deficient Neuromuscular Synapses of mdx Mice: A Study of Protected and Affected Muscles
Author(s) -
Ferretti Renato,
Neto Humberto Santo,
Marques Maria Julia
Publication year - 2011
Publication title -
the anatomical record: advances in integrative anatomy and evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.21297
Subject(s) - utrophin , dystrophin , acetylcholine receptor , neuromuscular junction , duchenne muscular dystrophy , regeneration (biology) , neuroscience , acetylcholine , mdx mouse , biology , anatomy , receptor , microbiology and biotechnology , skeletal muscle , medicine , endocrinology
In mdx mice, intrinsic laryngeal muscles are spared and sternomastoid muscles are affected, showing cycles of muscle regeneration. We observed that utrophin and acetylcholine receptors are fragmented only in affected muscles, providing further evidence that changes in the overall distribution of molecules at dystrophic neuromuscular junctions may be correlated with muscle regeneration. Anat Rec, 2011. © 2010 Wiley‐Liss, Inc.