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The Action Sites of Propofol in the Normal Human Brain Revealed by Functional Magnetic Resonance Imaging
Author(s) -
Zhang Hui,
Wang Wei,
Zhao Zhijing,
Ge Yali,
Zhang Jinsong,
Yu Daihua,
Chai Wei,
Wu Shengxi,
Xu Lixian
Publication year - 2010
Publication title -
the anatomical record: advances in integrative anatomy and evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.21289
Subject(s) - functional magnetic resonance imaging , magnetic resonance imaging , action (physics) , nuclear magnetic resonance , propofol , human brain , neuroscience , functional magnetic resonance spectroscopy of the brain , medicine , physics , psychology , radiology , anesthesia , quantum mechanics
Propofol has been used for many years but its functional target in the intact brain remains unclear. In the present study, we used functional magnetic resonance imaging to demonstrate blood oxygen level dependence signal changes in the normal human brain during propofol anesthesia and explored the possible action targets of propofol. Ten healthy subjects were enrolled in two experimental sessions. In session 1, the Observer's Assessment of Alertness/Sedation Scale was performed to evaluate asleep to awake/alert status. In session 2, images with blood oxygen level dependence contrast were obtained with echo‐planar imaging on a 1.5‐T Philips Gyroscan Magnetic Resonance System and analyzed. In both sessions, subjects were intravenously administered with saline (for 3 min) and then propofol (for 1.5 min) and saline again (for 10.5 min) with a constant speed infusion pump. Observer's Assessment of Alertness/Sedation Scale scoring showed that the subjects experienced conscious–sedative–unconscious–analepsia, which correlated well with the signal decreases in the anesthesia states. Propofol induced significant signal decreases in hypothalamus (18.2% ± 3.6%), frontal lobe (68.5% ± 11.2%), and temporal lobe (34.7% ± 6.1%). Additionally, the signals at these three sites were fulminant and changed synchronously. While in the thalamus, the signal decrease was observed in 5 of 10 of the subjects and the magnitude of decrease was 3.9% ± 1.6%. These results suggest that there is most significant inhibition in hypothalamus, frontal lobe, and temporal in propofol anesthesia and moderate inhibition in thalamus. These brain regions might be the targets of propofol anesthesia in human brain. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.