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Stereological Investigation of Age‐Related Changes of the Capillaries in White Matter
Author(s) -
Shao WeiHua,
Li Chen,
Chen Lin,
Qiu Xuan,
Zhang Wei,
Huang ChunXia,
Xia Lei,
Kong JiMing,
Tang Yong
Publication year - 2010
Publication title -
the anatomical record: advances in integrative anatomy and evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.21184
Subject(s) - white matter , stereology , atrophy , age groups , pathology , anatomy , medicine , psychology , physiology , magnetic resonance imaging , demography , radiology , sociology
We, for the first time, investigated the age‐related changes of the capillaries in white matter using immunohistochemistry and stereological techniques. Ten young female (7 months) and 10 aged female (27 months) rats were used. The total length, total volume, and total surface area of the capillaries in white matter of aged rats were all significantly lower than those of young rats. The age‐related changes of the capillaries in white matter may have important implications for age‐related white matter atrophy and age‐related cognitive impairments. Anat Rec 293:1400–1407, 2010. © 2010 Wiley‐Liss, Inc.