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Expression of Muscle Segment Homeobox Genes in the Developing Myocardium
Author(s) -
Boogerd Cornelis J.J.,
Moorman Antoon F.M.,
Barnett Phil
Publication year - 2010
Publication title -
the anatomical record: advances in integrative anatomy and evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.21112
Subject(s) - homeobox , cardiac muscle , anatomy , biology , microbiology and biotechnology , electrical conduction system of the heart , gene , medicine , gene expression , genetics , electrocardiography
Msx1 and Msx2 are essential for the development of many organs. In the heart, they act redundantly in development of the cardiac cushions. Additionally, Msx2 is expressed in the developing conduction system. However, the exact expression of Msx1 has not been established. We show that Msx1 is expressed in the cardiac cushions, but not in the myocardium. In Msx2 ‐null mice, Msx1 is not ectopically expressed in the myocardium. The absence of myocardial defects in the Msx2 knock‐out can therefore not be attributed to a redundant action of Msx1 in the myocardium. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.