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Impact of Ethanol on the Developing GABAergic System
Author(s) -
Isayama Ricardo Noboro,
Leite Paulo Emilio Correa,
Lima Jean Pierre Mendes,
Uziel Daniela,
Yamasaki Ednami
Publication year - 2009
Publication title -
the anatomical record: advances in integrative anatomy and evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.20966
Subject(s) - gabaergic , synaptogenesis , neuroscience , central nervous system , neurotransmitter , biology , inhibitory postsynaptic potential , psychology
Alcohol intake during pregnancy has a tremendous impact on the developing brain. Embryonic and early postnatal alcohol exposures have been investigated experimentally to elucidate the fetal alcohol spectrum disorders' (FASD) milieu, and new data have emerged to support a devastating effect on the GABAergic system in the adult and developing nervous system. GABA is a predominantly inhibitory neurotransmitter that during development excites neurons and orchestrates several developmental processes such as proliferation, migration, differentiation, and synaptogenesis. This review summarizes and brings new data on neurodevelopmental aspects of the GABAergic system with FASD in experimental telencephalic models. Anat Rec, 292:1922–1939, 2009. © 2009 Wiley‐Liss, Inc.