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Signaling by Neuronal Tyrosine Kinase Receptors: Relevance for Development and Regeneration
Author(s) -
Hausott Barbara,
Kurnaz Isil,
Gajovic Srecko,
Klimaschewski Lars
Publication year - 2009
Publication title -
the anatomical record: advances in integrative anatomy and evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.20964
Subject(s) - regeneration (biology) , receptor tyrosine kinase , receptor , relevance (law) , microbiology and biotechnology , signal transduction , platelet derived growth factor receptor , neuroscience , tyrosine kinase , biology , biochemistry , growth factor , political science , law
Receptor tyrosine kinase activation by binding of neurotrophic factors determines neuronal morphology and identity, migration of neurons to appropriate destinations, and integration into functional neural circuits as well as synapse formation with appropriate targets at the right time and at the right place. This review summarizes the most important aspects of intraneuronal signaling mechanisms and induced gene expression changes that underlie morphological and neurochemical consequences of receptor tyrosine kinase activation in central and peripheral neurons. Anat Rec, 292:1976–1985, 2009. © 2009 Wiley‐Liss, Inc.