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Rotation of Organizer Tissue Contributes to Left–Right Asymmetry
Author(s) -
Cui Cheng,
Little Charles D.,
Rongish Brenda J.
Publication year - 2009
Publication title -
the anatomical record: advances in integrative anatomy and evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.678
H-Index - 62
eISSN - 1932-8494
pISSN - 1932-8486
DOI - 10.1002/ar.20872
Subject(s) - presumption , asymmetry , nodal , fgf8 , biology , rotation (mathematics) , anatomy , genetics , geometry , physics , mathematics , receptor , quantum mechanics , political science , fibroblast growth factor , law
Current hypotheses regarding vertebrate left‐right asymmetry patterns are based on the presumption that genetic regulatory networks specify sidedness via extracellular morphogens and/or ciliary activity. We show empirical time‐lapse evidence for an asymmetric rotation of epiblastic nodal tissue in avian embryos. This rotation spans the interval when initial symmetric expression of Shh and Fgf8 becomes asymmetrical with respect to the midline. Anat Rec, 292:557–561, 2009. © 2009 Wiley‐Liss, Inc.