Open AccessExpression of bone morphogenetic protein‐5 gene during chick heart development: Possible roles in valvuloseptal endocardial cushion formation
Author(s) -
Yamagishi Toshiyuki,
Nakajima Yuji,
Nishimatsu ShinIchiro,
Nohno Tsutomu,
Ando Katsumi,
Nakamura Hiroaki
Publication year - 2001
Publication title -
the anatomical record
Language(s) - English
Resource type - Journals
eISSN - 1097-0185
pISSN - 0003-276X
DOI - 10.1002/ar.10013
Subject(s) - endoderm , mesoderm , bone morphogenetic protein , in situ hybridization , atrioventricular cushions , bone morphogenetic protein 5 , biology , heart development , microbiology and biotechnology , embryo , bone morphogenetic protein 2 , gene expression , anatomy , bone morphogenetic protein 7 , embryonic stem cell , gene , medicine , genetics , heart disease , in vitro
The bone morphogenetic protein (BMP) family, comprising multifunctional peptide growth factors, regulates many developmental processes in a variety of tissues. We examined the spatiotemporal expression of BMP5 by in situ hybridization in chick embryonic hearts from stages 5 to 33. The BMP5 gene was first expressed in the endoderm underlying the precardiac mesoderm at stages 5 to 8. Thereafter, BMP5 expression was restricted to the myocardium of the atrioventricular (AV) canal and outflow tract (OT) regions, where the valvuloseptal endocardial cushion tissue is induced. These results suggest that BMP5 may play important roles not only in myocardial differentiation, but also in the formation and maintenance of endocardial cushion tissue. Anat Rec 264:313–316, 2001. © 2001 Wiley‐Liss, Inc.