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Construction of porous cellulose tubes and the evaluations of mechanical properties and cytocompatibility
Author(s) -
Yang Wen,
Li Yifan,
Xiao Yuelong,
Hou Jianhua,
Tang Keyong,
Pei Ying
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.51399
Subject(s) - ultimate tensile strength , cellulose , materials science , biocompatibility , composite material , porosity , polymer , bacterial cellulose , chemical engineering , metallurgy , engineering
In this work, regenerated cellulose (RC) tubes with the porous structure were successfully fabricated for constructing the non‐invasive detection platform of vascular microenvironment. Polyethylene oxide (PEO) as a porogen was applied to induce porous structure of cellulose tubes. Tensile and burst pressure tests were carried out to evaluate the effects of PEO molecular weight and amount on the mechanical properties of cellulose tubes. The results showed that tensile strength of RC tubes was increased with increasing PEO molecular weight. The compliance of cellulose tubes decreased with increasing the PEO content. When 120 kDa PEO was applied, the average tensile strength of RC tubes could reach 1.27 MPa. The maximum burst pressure and compliance of RC tubes could reach 488.25 ± 35 mmHg and 7.50 ± 3.7%/100 mmHg, respectively. Human umbilical vein endothelia cells (HUVECs) exhibited obvious proliferation on cellulose tubes, and the collagen coating further improve the biocompatibility. The incorporated collagen further improved adhesion of the cells and growth on cellulose tubes. This work provided a kind of cellulose‐based tube material with potential application for the construction of the vitro vascular microenvironment.