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Thermal and dynamic mechanical behavior of poly(lactic acid) (PLA)‐based electrospun scaffolds for tissue engineering
Author(s) -
Ciarfaglia Nicola,
Laezza Antonio,
Lods Louise,
Lonjon Antoine,
Dandurand Jany,
Pepe Antonietta,
Bochicchio Brigida
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.51313
Subject(s) - materials science , thermal stability , gelatin , tissue engineering , polymer , elastin , electrospinning , lactic acid , composite material , chemical engineering , biomedical engineering , chemistry , organic chemistry , medicine , pathology , biology , bacteria , engineering , genetics
Electrospun scaffolds can find numerous applications, including biomedical; for example, tissue engineering. Poly‐L‐lactic acid is considered suitable for these applications, but its low‐thermal stability and its poor mechanical properties limit this polymer use. The aim of this work is to obtain a modulation of the final scaffolds characteristics such as fibers dimension, wettability, elasticity, and resistance to rupture through the choice of the polymers to be electrospun. Different electrospun scaffolds containing gelatin, Poly‐DL‐lactic acid, different percentages of cellulose nanocrystals and an elastin peptide have been produced. Thermal stability, physical structure, and its mechanical behavior have been studied. Results suggest that the electrospun scaffolds show better thermal and mechanical properties than bulk materials; that is, the scaffolds with the best hydrophilic and thermomechanical properties are the samples containing 3% (wt/wt) of CNCs and elastin peptide.