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On arginine‐based polyurethane‐blends specific to vascular prostheses
Author(s) -
ZumbardoBacelis Gualberto Antonio,
MezaVillegas Linnette Aracely,
PérezAranda Cesar Antonio,
VargasCoronado Rossana,
CastilloCruz Omar,
MontañoMachado Vanessa,
Mantovani Diego,
CauichRodríguez Juan Valerio
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.51247
Subject(s) - materials science , thermogravimetric analysis , differential scanning calorimetry , fourier transform infrared spectroscopy , polyurethane , ultimate tensile strength , thermal stability , nuclear chemistry , polymer chemistry , composite material , chemical engineering , chemistry , organic chemistry , physics , engineering , thermodynamics
Polymer blends based on Tecoflex™ and an experimental aliphatic polyurethane (HMDI‐PCL‐arginine stands for 4,4 (metylene‐biscyclohexyl) isocyanate ‐ poly (ε caprolactone) diol, SPUUR stands for segmented poly(urea)urethanes using amino acid of L‐Arginine as chain extender) were obtained by solvent casting, and further studied by fourier transform infrared (FTIR) and Raman spectroscopy, differential scanning calorimetry (DSC), thermogravimetric analysis, and X‐ray diffraction (XRD). Their biological performances were assessed in terms of hemocompatibility and Human umbilical vein endothelial cell (HUVEC) cytotoxicity. Tensile properties of dumbbell specimens were compared to longitudinal and circumferential tensile properties of tubular vascular graft. FTIR showed that as the SPUUR content increased in the blend, absorptions at 2860 cm −1 increased, carbonyl absorptions at 1724 cm −1 broaden and the small peak at 2796 cm −1 , typical of Tecoflex™ disappeared. Raman spectroscopy showed that the low intensity carbonyl absorption at 1724 cm −1 also increased with SPUUR content. DSC allowed detection of PCL soft segment melting ( T m = 50°C) in agreement with X‐ray reflections at 21.3° and 23.6°, assigned to SPUUR. However, no improvements in thermal stability were detected by TGA by blending. The addition of SPUUR to Tecoflex™ improved hemocompatibility and HUVEC cytotoxicity. The vascular grafts performance showed that 40% SPUUR blends exhibited the highest force in the longitudinal test whereas 50% SPUUR blends showed the highest circumferential force. Pressure burst strength was higher than 1000 mmHg for all blends. Overall, these blends can be used for high caliber vascular grafts.