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Biocompatible graphene‐embedded PCL / PGS ‐based nanofibrous scaffolds: A potential application for cardiac tissue regeneration
Author(s) -
Fakhrali Aref,
Nasari Mina,
Poursharifi Nazanin,
Semnani Dariush,
Salehi Hossein,
Ghane Mohammad,
Mohammadi Sajjad
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.51177
Subject(s) - biocompatibility , nanofiber , materials science , tissue engineering , polymer , polycaprolactone , polyester , graphene , regeneration (biology) , chemical engineering , adhesion , polyurethane , polymer chemistry , biomedical engineering , composite material , nanotechnology , microbiology and biotechnology , biology , medicine , engineering , metallurgy
Research in the field of tissue engineering, especially heart tissue engineering, is growing rapidly. Herein, the morphological, chemical, mechanical and biological properties of poly (caprolactone) (PCL)/poly (glycerol sebacate) (PGS) and PCL/PGS/graphene nanofibrous scaffolds are investigated. Initially, PGS pre‐polymer is synthesized and characterized by nuclear magnetic resonance and Fourier transform infrared spectroscopies. Then, in order to use the benefits of PGS, this polymer is mixed with PCL. Blending PGS with PCL resulted in the enhancement of ultimate elongation and reduction in the elastic modulus due to the intrinsic properties of PGS. The hydrophobicity of PCL nanofibers is reduced by adding PGS as hydrophilic polymer (105 ± 3° vs. 44 ± 2°). Also, the addition of graphene to the blend nanofibers is balanced the hydrophilicity. Degradation rate of pure PCL nanofibers is very slow but it is increased in the presence of PGS. All nanofibrous scaffolds are biocompatible and non‐toxic. The highest cell adhesion (covered area = 0.916 ± 0.032) and biocompatibility (98.79 ± 1%) are related to PCL/PGS loaded with 1% wt of graphene (PCL/PGS/graphene 1 ). Thus, this sample can be a good candidate for further examinations of cardiac tissue engineering.