Premium
PEGylated copper( II )‐chelated polydopamine nanocomposites for photothermal‐enhanced chemodynamic therapy against tumor cells
Author(s) -
Zhang Qiuye,
Wang Jingjing,
Xu Luen,
Lu ShiYu,
Yang Huawei,
Duan Yifan,
Yang Qiang,
Qiu Mengfan,
Chen Chunmei,
Zhao Sheng,
Liu Xiaohong,
Liu Hui
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.51172
Subject(s) - photothermal therapy , peg ratio , photothermal effect , ethylene glycol , chelation , chemistry , radical , dispersity , copper , nanoparticle , glutathione , biophysics , nuclear chemistry , materials science , polymer chemistry , nanotechnology , biochemistry , inorganic chemistry , organic chemistry , enzyme , finance , economics , biology
Photothermal‐enhanced chemodynamic therapy is a novel and promising strategy for effective tumor treatment. Herein, a kind of polydopamine (PDA)‐based nanoplatform is reported for photothermal‐enhanced chemodynamic therapy against tumor cells. PDA nanoparticles (NPs) were prepared through the self‐polymerization method, which were subsequently chelated with Cu 2+ and linked with poly(ethylene glycol) (PEG) chains, finally obtaining PDA‐Cu(II)‐PEG NPs. The fabricated PDA‐Cu(II)‐PEG NPs were uniform in shape with a narrow polydispersity. They can firstly react with glutathione (GSH) to generate Cu + , inducing GSH depletion meanwhile. The formed Cu + could catalyze H 2 O 2 to produce hydroxyl radicals (˙OH) via a Fenton‐like reaction. The formed PDA‐Cu(II)‐PEG NPs displayed good photothermal conversion efficiency and photothermal stability. They can be internalized by 4T1 cells effectively. Under near‐infrared light irradiation, PDA‐Cu(II)‐PEG NPs can generate hyperthermia and ˙OH for photothermal/chemodynamic therapy against tumor cells.