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Multifunctional zinc phthalocyanine‐phenolic resin ( ZnPc‐PFR )@ MSN nanocomposite based fluorescent imaging, photothermal therapy, and pH ‐sensitive drug release
Author(s) -
Sun Xiangfei,
Yang Ping,
Wang Shaohua,
Xing Honglong
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.50854
Subject(s) - photothermal therapy , fluorescence , photosensitizer , mesoporous silica , nanoparticle , nanocomposite , phthalocyanine , drug delivery , materials science , nuclear chemistry , zinc , chemistry , combinatorial chemistry , mesoporous material , photochemistry , nanotechnology , catalysis , organic chemistry , physics , quantum mechanics
Because of the good fluorescence of zinc phthalocyanine‐phenolic resin (ZnPc‐PFR) photosensitizer and large specific surface area of mesoporous silica nanoparticles (MSNs), a highly efficient nano‐drug carrier system, denoted as ZnPc‐PFR@MSN, was constructed for photothermal therapy (PTT) and pH‐sensitive drug delivery. The facile hydrothermal reaction was used to synthesize ZnPc‐PFR nanoparticles in one‐step. After loading the as‐synthesized ZnPc‐PFR nanoparticles into MSNs, and a good high drug‐loading rate (143.7 mg g −1 ) to the anticancer drug of Adriamycin (DOX) could be obtained. Thus, a novel nanosphere with the merits of good fluorescence, high drug‐loading rate (143.7 mg g −1 ), better sustained‐release properties, and photothermal properties (reached 43.23°C within 260 s) was prepared. The as‐synthesized multifunctional composites make it a good candidate in fluorescence imaging, PTT, and drug delivery.