Premium
Developing antibacterial surgical adhesives: An enhancement of cyanoacrylate polymers
Author(s) -
Stevens Rhianna,
Esteban Gabrielle,
Jenkins Emma,
Saitow Cassandra,
Gurney Rich
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.50538
Subject(s) - cyanoacrylate , copolymer , staphylococcus epidermidis , adhesive , antimicrobial , chemistry , antibacterial activity , polymer , monomer , microbiology and biotechnology , staphylococcus aureus , polymer chemistry , bacteria , biology , organic chemistry , layer (electronics) , genetics
Surgical site infections (SSIs) and traumatic wounds have a significant risk of becoming contaminated by microbial pathogens of both endogenous and nosocomial origins, including Staphylococcus aureus and Enterococci sp .. One preventative approach is to protect wounds from infection by using a rapidly curing adhesive to seal the wound and prevent further contamination. Here, we demonstrate the covalent incorporation of an antimicrobial, quaternary ammonium chloride monomer (quat) into a 2‐octyl cyanoacrylate (2oc) polymer adhesive. Copolymerization was confirmed via nuclear magnetic resonance spectroscopy. Cytotoxicity of the copolymer was assessed against: S. epidermidis and E. coli , and 3T3 mouse fibroblasts. The CA‐Quat polymer was found to exhibit dose‐dependent bacteriostatic and bactericidal effects against both E. coli and S. epidermidis , importantly without showing any demonstrable toxicity against mammalian 3T3 fibroblast cells. The described experiments provide promising data to suggest successful copolymerization, effective antibacterial properties, and remarkably low cytotoxic effects of the copolymer on mammalian cells.