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Development and characterization of a poly (vinyl alcohol) and sodium alginate blend foam for wound dressing loaded with propolis and all‐ trans retinoic acid
Author(s) -
Cesar Pedro Henrique Souza,
Natarelli Caio Vinicius Lima,
Oliveira Juliano Elvis de,
Andrade Paula Ariane,
Santos Tamara Leite,
Marcussi Silvana
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.50480
Subject(s) - vinyl alcohol , wound healing , propolis , biocompatibility , chitosan , retinoic acid , chemistry , anti inflammatory , granulation tissue , extracellular matrix , genipin , polymer , pharmacology , materials science , biomedical engineering , biochemistry , organic chemistry , medicine , surgery , food science , gene
Propolis is a complex mixture of phytochemicals, with antibacterial, anti‐inflammatory, and healing properties. All ‐trans retinoic acid is implicated in wound healing by stimulating angiogenesis, cell recruitment, extracellular matrix deposition, and reepithelization. The incorporation of both agents to a polymeric wound dressing composed of poly (vinyl alcohol) and sodium alginate may result in improved healing allied to controlled release, fluid uptake, and wound protection. In the present work, we have physically characterized this wound dressing and analyzed its release kinetics. The anti‐inflammatory capacity was assayed. SEM images showed a highly porous structure with a diverse morphology. FTIR spectra displayed a highly cross‐linked structure with both polymers connected by hydrogen bonds and acetal bridges. The wound dressings were able to retain great volumes of PBS. Propolis and vitamin A releasing behavior were maintained for 6 h. The concentrations of the biologically active substances were capable of promoting anti‐inflammatory action in an erythrocyte membrane stabilization model. The wound dressings obtained here showed adequate physical properties. The fabrication process did not affect the anti‐inflammatory capacity. Further tests are needed to ensure the biocompatibility and to assess other biological activities of the therapeutic agents.