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Silver‐doped biphasic calcium phosphate/alginate microclusters with antibacterial property and controlled doxorubicin delivery
Author(s) -
Nie Lei,
Deng Yaling,
Zhang Yingying,
Zhou Qiuju,
Shi Qimin,
Zhong Shengping,
Sun Yi,
Yang Zhong,
Sun Meng,
Politis Constantinus,
Shavandi Amin
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.50433
Subject(s) - materials science , transmission electron microscopy , antibacterial activity , biocompatibility , scanning electron microscope , nanoparticle , nuclear chemistry , emulsion , doxorubicin , silver nanoparticle , drug delivery , chemical engineering , doping , nanotechnology , chemistry , composite material , bacteria , metallurgy , optoelectronics , medicine , surgery , chemotherapy , biology , engineering , genetics
Biphasic calcium phosphate (BCP) based materials possessed with both excellent biocompatibility and antibacterial activity show potential advantages for biomedical applications. Here, the silver‐doped BCP/Alginate ( Ag BA) microclusters were first fabricated using the double‐emulsions method. First, BCP nanoparticles were incorporated into the alginate network to form BCP/Alginate microclusters via the emulsion process. Then, silver nanoparticles (AgNPs) were in situ involved in BCP/Alginate networks to obtain the final Ag BA microclusters. Transmission electron microscopy and scanning electron microscopy confirmed that BCP nanoparticles and AgNPs were uniformly distributed in Ag BA microclusters. The morphology of Ag BA microclusters could be regulated by adjusting emulsion power, and microclusters using the medium powder (500 W) showed a regular spherical shape. Furthermore, CCK‐8 analysis identified that Ag BA microclusters were cytocompatible culturing with human bone marrow‐derived mesenchymal stem cells. Qualitative antibacterial tests exhibited the excellent inhibition effects of Ag BA microclusters against Staphylococcus aureus (Gram‐positive) and Escherichia coli. (Gram‐negative). Lastly, the doxorubicin (DOX)‐loaded Ag BA microclusters presented adjustable loading efficiency of DOX and controllable release profiles. The cumulative release could reach 73.3% after 72 h in PBS. The above results raised a new route for antibacterial microclusters development for biomedical applications.