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Four modified sodium alginate/carboxymethylcellulose blends for prednisone delivery
Author(s) -
Silva Kláudia Maria Machado Neves,
Costa Bruna Lopes,
Dourado Lays Fernanda,
Silva Rummenigge Oliveira,
SilvaCunha Armando,
Santos Anderson Kenedy,
Resende Rodrigo Ribeiro,
Faria Paulo Eustáquio,
Campos Rubio Juan Carlos,
Goulart Gisele Assis Castro,
SilvaCaldeira Priscila Pereira
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.50383
Subject(s) - biocompatibility , epichlorohydrin , drug delivery , materials science , cellulose , chemical engineering , hydrolysis , fibroin , chemistry , nuclear chemistry , polymer chemistry , organic chemistry , composite material , silk , engineering
Abstract Polysaccharides have been widely used for the development of drug delivery systems. These systems can be physicochemically modified to enhance their stabilities and control their drug release profiles. However, such modifications cannot alter their biocompatibility or toxicity. Herein, four structurally modified sodium alginate/carboxymethylcellulose blends are synthesized and loaded with prednisone, and the effects of the modifications on their hydrolytic degradation rates, biocompatibilities, toxicities, and drug release profiles are investigated. All the blends are ionically cross‐linked with Ca 2+ and Fe 3+ . Blend 1 is not modified further, blend 2 is additionally reinforced with 8% w/w of cellulose nanocrystals, blend 3 is treated with epoxidized linseed oil to develop a hydrophobic layer, and blend 4 is chemically cross‐linked with epichlorohydrin. Blends 2 and 4 exhibit similar physicochemical characteristics, appropriate hydrolytic degradation rates and drug release patterns, as well as biocompatibility and non‐toxicity. In‐vitro studies using the osteoblasts and CAM assay demonstrate that blends 2 and 4 are also biocompatible and non‐toxic. In contrast, blend 1 exhibits the highest drug release rate, followed by blend 3.