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New polyester biodegradable scaffolds for chondrocyte culturing: Preparation, properties, and biological activity
Author(s) -
GadomskaGajadhur Agnieszka,
Kruk Aleksandra,
Dulnik Judyta,
Chwojnowski Andrzej
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.50089
Subject(s) - polyester , scaffold , materials science , tissue engineering , phase inversion , polymer , chondrocyte , chemical engineering , composite material , biomedical engineering , chemistry , in vitro , membrane , medicine , biochemistry , engineering
An innovative modification of the wet inversion phase method, consisting in the use of a polymer nano‐nonwoven as a nonclassic pore precursor. Mechanical properties of the obtained scaffolds were determined, their hydrophilic properties (serum absorbability) were tested, and the content of residues of materials used in the scaffold preparation was determined. Nontoxicity of the developed scaffolds toward T lymphocyte cells was proved. Cultures of primary chondrocytes were obtained successfully. It was proved that an addition of a polymer nano‐nonwoven changes the properties of the scaffolds favorably in respect of their subsequent application in tissue engineering.