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Development of gum odina‐gelatin based antimicrobial loaded biodegradable spongy scaffold: A promising wound care tool
Author(s) -
Das Shilpa,
De Arnab,
Das Bhaskar,
Mukherjee Biswajit,
Samanta Amalesh
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.50057
Subject(s) - gelatin , antimicrobial , swelling , scaffold , biomaterial , materials science , biodegradation , biomedical engineering , drug , biocompatible material , chemistry , nanotechnology , composite material , pharmacology , organic chemistry , medicine
The present study focuses on development of HPMC K100M reinforced antimicrobial loaded spongy biodegradable wound dressing scaffold by blending gum odina (GO) and gelatin (G) which has not been explored so far. All the prepared formulations by varying GO‐HPMC K100M: G are subjected to physicochemical evaluations (visual appearance, swelling study, biodegradability, drug loading, and drug release). F3B (GO‐HPMC K100M: G = 1:1, blank) and F3D (GO‐HPMC K100M: G = 1:1, drug loaded) are optimized and selected for further evaluations. Controlled degradation and sustained release of impregnated drug molecules from F3D may influence the antimicrobial efficacy. A satisfactory result of protein adsorption on the surface of F3B and F3D (almost 24%) can be an important event for being a biomaterial. The safe value of hemolytic potentiality (approximately 4%) may consider as biocompatible in nature. Furthermore, upon other characterizations F3B and F3D can be considered as an excellent potential candidate for biomedical application.