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Preparation and characterization of ethanol‐induced chitosan‐glutaric anhydride hydrogel for biomedical applications
Author(s) -
Lei Zhou,
Huang Ruiqi,
Li Xuqin,
Fang Zhou,
Sheng Jie,
Song Yishan
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.49988
Subject(s) - chitosan , self healing hydrogels , swelling , ethanol , nuclear chemistry , polymer chemistry , chemistry , acylation , antimicrobial , fourier transform infrared spectroscopy , materials science , organic chemistry , chemical engineering , engineering , composite material , catalysis
Here we report a novel, fast, and facile sythesis of chitosan‐based hydrogels by ethanol directly inducing. In the present of ethanol, chitosan (CS) with glutaric anhydride (GA) could form hydrogels (CS‐GA‐Hs) just in few minutes. The results of 1 H NMR and FTIR confirmed N‐acylation substitution of chitosan. Furthermore, the relative concentration of GA was also the critical parameter for formation and properties of CS‐GA‐Hs. When the concentration was 1.5, CS‐GA‐Hs showed the highest swelling (253.6%) and release degree (99.9%). The porous structure of CS‐GA‐Hs were observed by SEM and the pore size of the gels decreased from 500 to 200 μm, when the relative concentration of GA was changed from 1.5 to 4. And all the hydrogels were demonstrated a good mechanical properties. Additionally, the CS‐GA‐Hs showed in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli , and no cytotoxicity toward L929 mouse fibroblasts, meaning it has potential applications in biomedical fields.