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Preparation of antibacterial biocompatible polycaprolactone/keratin nanofibrous mats by electrospinning
Author(s) -
Wang Yang,
Wang Yingfeng,
Li Lin,
Zhang Yan,
Ren Xuehong
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.49862
Subject(s) - electrospinning , polycaprolactone , biocompatibility , materials science , nanofiber , chemical engineering , antibacterial activity , fourier transform infrared spectroscopy , nuclear chemistry , keratin , polymer chemistry , composite material , chemistry , bacteria , polymer , medicine , pathology , biology , engineering , metallurgy , genetics
Keratin‐based materials are widely used in biomedical applications due to excellent biocompatibility and biodegradability. In this study, keratin was extracted from waste wool fibers and blended with polycaprolactone (PCL) to produce PCL/keratin nanofibrous mats by electrospinning. The electrospun PCL/keratin nanofibrous mats were chlorinated in diluted sodium hypochlorite solution to endow antibacterial properties. The prepared nanofibrous mats were characterized by scanning electron microscopy, X‐ray photoelectron, and Fourier infrared spectroscopy. The effect of the chlorination time on the active chlorine loading of the mats was investigated. The chlorinated PCL/keratin nanofibrous mats with 0.78 ± 0.009 wt% active chlorine displayed potent antibacterial activity against Gram‐positive Staphylococcus aureus (ATCC 6538) and Gram‐negative Escherichia coli O157:H7 (ATCC 43895) with 6.88 and 6.81 log reductions, respectively. It was found that the mats were compatible with mouse fibroblast cells (L929). The chlorinated PCL/keratin nanofibrous mats might find promising applications in the biomedical field.