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Facile fabrication of elongated polymer micro/nano discs and their surface adhesiveness
Author(s) -
Tuntanatewin Waranyou,
Mekwatanakarn Pinyo,
Zhang Hong,
Okamura Yosuke
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.49798
Subject(s) - materials science , polymer , coating , polyvinyl alcohol , elongation , adhesion , contact angle , plga , nanoparticle , composite material , nano , particle (ecology) , fabrication , contact area , spheres , nanotechnology , medicine , alternative medicine , pathology , oceanography , physics , astronomy , geology , ultimate tensile strength
The key factor of polymer particles using as a drug carrier is the ability to adhere to the surface of the target sites in order to optimize the drug delivery efficiency. To this end, shape of the particles is one of the essential parameters since nonspherical particles such as discs theoretically have more contact surface area than spherical particles. We herein propose a facile method to fabricate elongated polymer micro/nano discs by combining phase separation and a roll‐to‐roll coating process with a stretching method. By roll‐to‐roll coating, biodegradable poly(lactide‐co‐glycolide) (PLGA) discs formed on polyvinyl alcohol (PVA) film can be instantly stretched by uniaxial stretcher. The effect of stretching temperature and percentage of film elongation on the particle morphology was studied. The results showed that the PLGA discs can be elongated and the aspect ratio of 2.3 can be achieved with 600% elongation at 80°C, reflecting the increase of estimated contact surface area by 1.8 times. The adhesion efficiency of these elongated discs was compared with discs before stretching, spheres, and elongated spheres by using the water‐dropping test. The elongated discs showed the best result among these particles and their adhesion efficiency are strongly related to estimated contact surface area.