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Sustained‐release ibuprofen prodrug particle: Emulsifier and initiator regulate the diameter and distribution
Author(s) -
Wang Jia,
Zhang Haixin,
Xu Jie,
Qian Hao,
Liu Rui,
Xu Zengchang,
Zhu Hongjun
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.49779
Subject(s) - dispersity , ethylene glycol dimethacrylate , materials science , monomer , ethylene glycol , polymer chemistry , drug delivery , emulsion polymerization , fourier transform infrared spectroscopy , polymer , chemical engineering , methyl methacrylate , particle size , emulsion , chemistry , organic chemistry , methacrylic acid , nanotechnology , composite material , engineering
Polymers have played a vital part in the development of drug delivery systems (DDS). For DDS, having a controllable diameter and distribution are conducive to reproducibility of drug release behavior and efficacy. In this work, an ibuprofen prodrug (Ibu@PMMA) was synthesized by methyl methacrylate (MMA), ibuprofen monomer (Ibu@HEMA), and ethylene glycol dimethacrylate (EGDMA) via emulsion polymerization. The Ibu@PMMA exhibits spherical shapes, and its structural properties were characterized by NMR, FTIR, and SEM techniques. In addition, the hydrodynamic diameter and polydispersity index (PDI) of Ibu@PMMA were reduced by increasing the proportion of emulsifier. Meanwhile, by increasing the amount of initiator, the hydrodynamic diameter and PDI of Ibu@PMMA were decreased. Moreover, Ibu@PMMA exhibits good sustained‐release ability in vitro , which could be used as a potential delivery system for anti‐inflammatory agents.