Premium
Near infrared light‐induced disassembly of polymeric micelles based on methylene blue conjugated polyethylene glycol
Author(s) -
Dao Huy Minh,
Pillai Amit Raviraj,
Thakkar Rishi,
Parajuli Sanjiv,
UrenaBenavides Esteban,
Jo Seongbong
Publication year - 2021
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.49665
Subject(s) - polyethylene glycol , moiety , conjugated system , micelle , polymer , methylene blue , peg ratio , amphiphile , photochemistry , irradiation , materials science , chemistry , aqueous solution , copolymer , organic chemistry , physics , finance , photocatalysis , nuclear physics , economics , catalysis
Abstract Light‐sensitive drug delivery systems are considered ideal for applications in the biomedical fields for their ability to release the payload in an on‐demand spatiotemporal controlled manner through the manipulation of the light source. Among the broad radiation spectrum, near infrared (NIR) light is considered advantageous compared to UV and visible light, due to its inherently lower photodamage to normal tissues and deeper penetration to lesion areas. In this study, we report a successful synthesis of a polymer capable of undergoing partial degradation upon irradiation with NIR light by conjugating 10‐ N ‐carbamoyl linkage methylene blue (MB) moiety, a NIR photocleavable ligand, with polyethylene glycol (PEG). Through effective coupling of MB, a hydrophobic moiety, to the hydrophilic PEG molecule, an amphiphilic polymer was synthesized, as demonstrated by a lowered surface tension (55 mN/m at 0.1% wt/vol). Subsequently, photo‐induced reversal of surface activity associated with self‐assembled structure disruption, was displayed by surface tension measurements, size distribution analysis, and burst release profile of paclitaxel (PTX) from polymeric micelles upon the exposure to NIR irradiation.