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Gelatin micro‐ and nanocapsules obtained via sonochemical method
Author(s) -
Yankova Iveta,
Shestakova Pavletta,
Reis Rui L.,
Pashkuleva Iva,
Vassileva Elena
Publication year - 2020
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.49584
Subject(s) - gelatin , sonication , nanocapsules , dynamic light scattering , isoelectric point , chemical engineering , materials science , scanning electron microscope , chemistry , controlled release , chromatography , nanotechnology , nanoparticle , organic chemistry , composite material , engineering , enzyme
Gelatin capsules (GCs) with mean size between 200 and 400 nm are prepared via sonochemical method. Their size is low that the usual size for the sonochemically obtained protein capsules and depends on the preparation conditions. The nanometer size of GCs is explained by the low‐gelatin concentration and by the denaturated state of gelatin. The influence of pH, sonication time, and temperature on GCs size is investigated. An increase in temperature and sonication time results into GCs size increase. The pH dependence of GCs size passes through a minimum at the isoelectric point of gelatin. The broad size distribution detected by dynamic light scattering and scanning electron microscopy is explained by the broad molecular weight distribution of gelatin. GCs are successfully applied for encapsulation of two hydrophobic drugs, α‐tocopherol and acetylsalicylic acid, in order to demonstrate the versatility of the sonochemical method for drug encapsulation. In the case of α‐tocopherol drug entrapment efficiency as high as 95% is obtained.