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A hybrid system of hydrogel/frog egg‐like microspheres accelerates wound healing via sustained delivery of RCSPs
Author(s) -
Ji Xuan,
Liu Guomin,
Cui Yutao,
Jia Wenyuan,
Luo Yungang,
Cheng Zhiqiang
Publication year - 2020
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.49521
Subject(s) - gelatin , biocompatibility , wound healing , self healing hydrogels , in vivo , biomedical engineering , materials science , microsphere , chemistry , chemical engineering , polymer chemistry , surgery , medicine , biochemistry , biology , microbiology and biotechnology , engineering , metallurgy
In this article, a hybrid system of hydrogel/frog egg‐like microspheres (H‐FMS) formed by the combination of coaxial electrostatic spraying and freeze‐drying was introduced for enhancing wound healing efficiency through the sustained release of Rana chensinensis skin peptides (RCSPs). The porous PVA/gelatin hydrogel were obtained and frog egg‐like microspheres (FMS) of sodium alginate (SA), shaping uniform and smooth, were embedded into hydrogel. Based on PVA/gelatin hydrogel, the FMS addition increased the water absorption of hydrogel to 1,105%. RCSPs were more effectively encapsulated into FMS than solid microspheres (MS). Not only does the H‐FMS act as good “depots” for sustained release of RCSPs over 9 days, without exhibiting obvious burst release, but also show good biocompatibility in vitro. In vivo studies on wound healing as well as the histology of fibroblasts, re‐epithelialization, inflammation, and hair follicles indicated that the structure of H‐FMS released RCSPs continuously and promoted wound healing in rats significantly.