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Synthesis of amino‐cosubstituted polyorganophosphazenes and fabrication of their nanoparticles for anticancer drug delivery
Author(s) -
Khan Rizwan Ullah,
Yu Haojie,
Wang Li,
Teng Lisong,
Nazir Ahsan,
Fahad Shah,
Elshaarani Tarig,
Haq Fazal,
Shen Di
Publication year - 2020
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.49424
Subject(s) - camptothecin , drug , nanoparticle , drug delivery , anticancer drug , polymer , permeation , drug carrier , chemistry , targeted drug delivery , nanotechnology , combinatorial chemistry , materials science , pharmacology , organic chemistry , biochemistry , membrane , medicine
The development of safe drug carriers is cardinal in cancer therapy, which can target the cancer cells and release the loaded drug on‐demand without damaging the healthy cells of the body. In our work, we synthesized three different biodegradable polymers, poly[(ethyl aminobezoate) (ethyl glycinato) phosphazenes] (PABGPs), in different mole ratio of side groups. The successful synthesis of these PABGPs was confirmed by 1 H NMR, 31 P NMR, FT‐IR, and gel permeation chromatography. These PABGPs were fabricated into drug (camptothecin, CPT, a hydrophobic anticancer drug) loaded nanoparticles. These drug‐loaded nanoparticles showed good drug release behaviors under normal physiological conditions (pH 7.4 and temperature 37°C). These PABGPs‐based nanoparticles may find their application as effective drug carriers for cancer therapy.