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Phase behavior, in vitro drug release, and antibacterial activity of thermoresponsive poloxamer– polyvinyl alcohol hydrogel‐loaded mupirocin nanoparticles
Author(s) -
Kamlungmak Sukanjana,
Rugmai Supagorn,
Tinpun Kittiya,
Nakpheng Titpawan,
Srichana Teerapol
Publication year - 2020
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.49325
Subject(s) - mupirocin , self healing hydrogels , polyvinyl alcohol , poloxamer 407 , staphylococcus epidermidis , staphylococcus aureus , chemistry , poloxamer , microbiology and biotechnology , materials science , nuclear chemistry , polymer chemistry , organic chemistry , methicillin resistant staphylococcus aureus , bacteria , copolymer , polymer , biology , genetics
This research was designed to develop thermoresponsive poloxamer (P407)–polyvinyl alcohol (PVA) hydrogels to deliver mupirocin nanoparticles for wound healing. The mupirocin nanoparticles containing drug and gelatin or poly (acrylic acid) were prepared by spray drying. The hydrogel phases were evaluated by small‐angle X‐ray scattering. An in vitro drug release study was performed and the antibacterial activity of mupirocin nanoparticles‐loaded hydrogel (MLH) was evaluated. Fourier transform infrared and proton nuclear magnetic resonance spectrum spectra of the mupirocin nanoparticles indicated a weak interaction between mupirocin and the carriers of carbopol and gelatin. The mupirocin molecules were surrounded by the carrier molecules. The MLH appeared to exhibit single diamond (Fd3m) phase behavior similar to P407 and the hydrogel base. The release of MLH in vitro indicated first‐order kinetics ( R 2 = .9839–.8868). The MLH showed lower minimum inhibitory concentrations and minimum bactericidal concentrations against Staphylococcus aureus , Staphylococcus epidermidis , Pseudomonas aeruginosa , and Escherichia coli than mupirocin ointment.