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Determination of tylosin in milk samples by poly(ethylene terephthalate)‐based molecularly imprinted polymer
Author(s) -
Garza Montelongo Elisa,
Sánchez Anguiano María G.,
Blanco Jerez Leonor M.,
Pereira Ulloa Eduardo D.,
Rivas Quiroz Bernabé L.,
Elizondo Martínez Perla
Publication year - 2020
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.49204
Subject(s) - molecularly imprinted polymer , tylosin , cartridge , solid phase extraction , adsorption , extraction (chemistry) , chromatography , detection limit , aqueous solution , polymer , sorbent , materials science , langmuir adsorption model , chemistry , organic chemistry , selectivity , composite material , biochemistry , metallurgy , catalysis , antibiotics
Poly(ethylene terephthalate)‐based molecularly imprinted polymers (MIPs) were synthesized, and their recognition capability was evaluated. Adsorption isotherm was described by the Langmuir model and the maximum adsorption capacity of MIP Ty reached 172.4 mg g −1 in water at pH 6.2. A recognition coefficient of 1.17 was obtained. A solid‐phase extraction cartridge was manufactured and its behavior was evaluated for tylosin extraction from aqueous and milk samples. An off‐line SPE‐UV method was applied. An acceptable linearity was obtained in the range of 1–20 μg ml −1 and the average recovery at three spike levels in milk samples was higher than 92%. The limit of quantification was 2.6 × 10 −2 μg ml −1 . The manufactured SPE cartridge has a great potential for clean‐up processes in complex media. The cartridge offers a fast and sensitive option to the existing sorbents for extracting this drug from milk samples.