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Multifunctional mussel‐inspired Gelatin and Tannic acid‐based hydrogel with pH‐controllable release of vitamin B 12
Author(s) -
Nath Jayashree,
Saikia Priyanka Pratim,
Handique Junali,
Gupta Kuldeep,
Dolui Swapan Kumar
Publication year - 2020
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.49193
Subject(s) - self healing hydrogels , gelatin , tannic acid , swelling , materials science , adhesive , chemical engineering , drug delivery , fourier transform infrared spectroscopy , controlled release , nanotechnology , polymer chemistry , composite material , chemistry , organic chemistry , layer (electronics) , engineering
Hydrogels have emerged to be an impeccable material for a large variety of applications over the past few decades. In the field of biomedical applications, remarkable progress has been observed in the effort of fabricating numerous hydrogel systems. In this work, gelatin and tannic acid‐based stretchable and adhesive hydrogel has been synthesized to study the release behavior of vitamin B 12 . Successful formation of the synthesized hydrogels was confirmed by Fourier transform infrared and X‐ray diffraction analysis. The morphology of the surfaces and the cross section of such hydrogels were studied with Scanning electron microscopy analysis. Swelling behavior of our hydrogel was studied with Design Expert software. The maximum swelling of the hydrogel was found to be around 137 g/g. Adhesive property was demonstrated on various surfaces to observe the adhesiveness of the fabricated hydrogel. Blood compatibility study was also performed. The release behavior of vitamin B 12 was performed in two different pH media and it was found to have enhanced value in the fluid mimicking the intestine. This work provides a new prospect for designing hydrogels with stretchable and adhesive properties with pH‐controllable drug delivery applications along with other promising applications in various fields of research.