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Crosslinked, biodegradable polyurethanes for precision‐porous biomaterials: Synthesis and properties
Author(s) -
Calleros Erasmo Lopez,
Simonovsky Felix I.,
Garty Shai,
Ratner Buddy D.
Publication year - 2020
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.48943
Subject(s) - polycaprolactone , materials science , microporous material , acrylate , porosity , degradation (telecommunications) , polymer , polyester , biodegradation , biodegradable polymer , swelling , chemical engineering , hydrolysis , hydrolytic degradation , polymer chemistry , composite material , copolymer , chemistry , organic chemistry , engineering , telecommunications , computer science
Crosslinked poly(ester urethane)s and their acrylate derivatives based on trifunctional polycaprolactone and trifunctional aliphatic isocyanates were synthesized. Biodegradable scaffolds with uniform, controlled micron‐scale porosity were fabricated with these materials. Mechanical and swelling properties of monolithic and microporous materials were studied. Cytotoxicity, hydrolytic, and enzymatic degradation and their effects on mechanical properties of the biodegradable scaffolds were investigated. The polymer degradation products were found not to be cytotoxic at moderate concentrations and to permit cell attachment and spreading. Degradation rates and mechanical properties could be tuned to desired performance criteria for a given application by adjusting crosslink density and the ratio of hard segment to soft segment. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48943.