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Nano‐enabled poly(vinyl alcohol) based injectable bio‐nanocomposite hydrogel scaffolds
Author(s) -
Phogat Kapender,
Kanwar Susheem,
Nayak Debabrata,
Mathur Navya,
Ghosh Subrata Bandhu,
BandyopadhyayGhosh Sanchita
Publication year - 2020
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.48789
Subject(s) - vinyl alcohol , nanocellulose , nanocomposite , self healing hydrogels , materials science , crystallinity , fourier transform infrared spectroscopy , chemical engineering , cellulose , polymer , composite material , polymer chemistry , engineering
We report development of poly(vinyl alcohol) (PVA)‐based novel injectable hydrogel nanocomposite scaffolds. Nanocellulose (NC), synthesized from agricultural biomass, was used as reinforcement within PVA matrix. The hydrogels were formed using physical crosslinking process involving multiple freeze–thaw cycles. A range of bio‐nanocomposite hydrogels were prepared with varying concentrations of NC. With increasing loading of NC, crystallinity was found to be increased, which could be attributed to nucleating effect and crystalline nature of nanofibrillar cellulose. Investigation of microstructural surface topology indicated reduced surface perturbations upon incorporation of NC. Fourier transform infrared spectroscopy studies further indicated presence of characteristic functional groups and possible interactions between PVA and NC. Enhanced structural integrity and dynamic stability of the bio‐nanocomposite hydrogels were also confirmed by carrying out rheological investigations at different frequency, amplitude, temperature, and time sweeps. Further, the bio‐nanocomposite hydrogels demonstrated excellent injectability and self‐standing behavior, establishing the promising potential as injectable scaffolds. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48789.