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Fabrication of althea officinalis loaded electrospun nanofibrous scaffold for potential application of skin tissue engineering
Author(s) -
Ghaseminezhad Keyhan,
Zare Mohadeseh,
Lashkarara Saba,
Yousefzadeh Maryam,
Aghazadeh Mohandesi Jamshid
Publication year - 2020
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.48587
Subject(s) - electrospinning , gelatin , nanofiber , scaffold , materials science , tissue engineering , ultimate tensile strength , biomedical engineering , wound healing , polymer , chemistry , nanotechnology , composite material , surgery , organic chemistry , medicine
ABSTRACT The Althea Officinalis (AO) extract is well known as a traditional herbal drug for its wound healing ability owing to the anti‐inflammatory and antimicrobial properties. Furthermore, its mucilaginous properties provide moisturizing and nutritional effects on skin cell proliferation. Therefore, AO extract can be applied in the temporary skin substitute for the ability to expedite the therapy duration. In this study, different concentrations of AO extract (0, 5, 10, 15, and 20 wt %) were incorporated into the nanofibrous scaffolds to study their potential for the skin tissue repairing. The desired scaffolds were prepared by electrospinning the blend of poly( ε ‐caprolactone) and gelatin as a synthesized and natural polymer. The electrospun nanofibers were characterized by SEM, FTIR, DSC, TGA, tensile, AO extract release, and cellular culture tests. This study proposed incorporating the AO extract into the nanofibrous scaffolds for accelerating the skin tissue repairing and the optimized amount of AO extract as about 15% was introduced for offering the most desirable electrospun scaffolds for this application. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48587.