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Design and characterization of PNVCL‐based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs
Author(s) -
Sta Marwa,
Aguiar Graziele,
Forni Abilio A. J.,
Medeiros Simone F.,
Santos Amilton M.,
Demarquette Nicole R.
Publication year - 2020
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.48472
Subject(s) - electrospinning , ketoprofen , nanofiber , materials science , chemical engineering , drug delivery , caprolactone , polymer , controlled release , lower critical solution temperature , drug carrier , scanning electron microscope , polymer chemistry , copolymer , nanotechnology , chemistry , composite material , chromatography , engineering
In this work, nanofiber scaffolds for surface drug delivery applications were obtained by electrospinning poly( N ‐vinylcaprolactam) (PNVCL) and its blends with poly(ε‐caprolactone) and poly( N ‐vinylcaprolactam)‐ b ‐poly(ε‐caprolactone). The process parameters to obtain smooth and beadless PNVCL fibers were optimized. The average fibers diameter was less than 1 μm, and it was determined by scanning electron microscopy analyses. Their affinity toward water was evaluated by measuring the contact angle with water. The ketoprofen release behavior from the fibers was analyzed using independent and model‐dependent approaches. The low values of the release exponent ( n < 0.5) obtained for 20 and 42 °C, indicating a Fickian diffusion mechanism for all formulations. Dissolution efficiencies (DEs) revealed the effect of polymer composition, methodology used in the electrospinning process, and temperature on the release rate of ketoprofen. PNVCL/poly( N ‐vinylcaprolactam)‐ b ‐poly(ε‐caprolactone)‐based nanofibers showed greater ability to control the in vitro release of ketoprofen, in view of reduced kinetic constant and DE, making this material promising system for controlling release of hydrophobic drugs. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48472.