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Construction of a sandwich‐type wound dressing with pain‐reliever and pH‐responsive antibiotic delivery system
Author(s) -
OzdabakSert Ayse Buse,
Sen Beren,
Kok Fatma Nese
Publication year - 2019
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.48252
Subject(s) - glutaraldehyde , chitosan , ibuprofen , gelatin , ciprofloxacin , ciprofloxacin hydrochloride , chemistry , staphylococcus aureus , microsphere , antimicrobial , gentamicin , antibiotics , microbiology and biotechnology , materials science , chromatography , pharmacology , bacteria , medicine , chemical engineering , organic chemistry , biochemistry , biology , engineering , genetics
A multifunctional sandwich type wound dressing was designed in which two types of microspheres, one to alleviate the pain (ibuprofen) and the other to protect the wound from infections (Gentamicin or Ciprofloxacin), were embedded into bilayer chitosan sponge. pH of the wound increases from acidic (pH ~ 5) to basic (pH ~ 8) via infection, so pH‐dependent antibiotic release system was designed using gelatin B microspheres to respond to increasing pH. Ibuprofen release from chitosan microspheres, on the other hand, was pH‐independent not to intervene with pain management in changing pH conditions. Crosslinking with glutaraldehyde (GA) affected both release profile and size distribution of microspheres and 2.5% GA was chosen to obtain pH‐responsive gelatin microspheres with narrow size distribution (80% of microspheres in between 15 and 25 μm). The final system was found to be effective against both Staphylococcus aureus and Escherichia coli and changing pH seemed to affect the antimicrobial agent delivery as desired. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 48252.