Premium
Influence of aorta extracellular matrix in electrospun polycaprolactone scaffolds
Author(s) -
Reid James A.,
Callanan Anthony
Publication year - 2019
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.48181
Subject(s) - polycaprolactone , extracellular matrix , scaffold , biomedical engineering , materials science , umbilical vein , stiffness , electrospinning , tissue engineering , polymer , composite material , chemistry , medicine , biochemistry , in vitro
ABSTRACT Cardiovascular disease is the leading cause of mortality worldwide. Therefore, new research strategies for the treatment of cardiovascular disease are required. Previously, extracellular matrices (ECMs) have been used alongside polymers to generate hybrid bioscaffolds. Herein, we propose combining aortic ECMs with a polycaprolactone electrospun scaffold and biomechanically evaluating the scaffolds. We electrospun three scaffolds with varying ECM concentrations and found that increasing the ECM concentration leads to decreased stiffness at low strains, increased elasticity at high strain, reduction in failure strain, and an increase in yield strength. We also noted a decrease in water droplet contact angle with the increasing ECM concentration. Furthermore, we found that all three scaffolds were capable of maintaining human umbilical vein endothelial cell attachment and survival. These findings show the wide spectrum of mechanical properties that can be achieved through the addition of different concentrations of ECM into the fibers. © 2019 The Authors. Journal of Applied Polymer Science published by Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 48181.