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Swelling degree prediction of polyhydroxybutyrate/chitosan matrices loaded with “ Arnica‐do‐Brasil”
Author(s) -
Silva Glauco Fonseca,
Silva Talita Goulart,
Gobbi Vinícius Guedes,
Portela Theresa Lomeu,
Teixeira Bruunes,
Santos Mendonça Tiago,
Silva Moreira Thiré Rossana Mara,
Oliveira Renata Nunes,
Yaunner Ricardo Stutz,
Almeida Rodrigues Junior Jorge,
Mendonça Roberta Helena
Publication year - 2019
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.47838
Subject(s) - polyhydroxybutyrate , swelling , chitosan , materials science , biocompatibility , drug delivery , biodegradation , chemical engineering , fourier transform infrared spectroscopy , absorption of water , polymer chemistry , composite material , chemistry , organic chemistry , nanotechnology , genetics , bacteria , engineering , biology , metallurgy
Polyhydroxybutyrate and chitosan have been studied as materials for drug delivery systems (DDSs) due to their biodegradability and biocompatibility. The aim of this work was to produce amphiphilic polyhydroxybutyrate/chitosan matrices that form porous structures (scaffolds) after swelling in water and arnica extract. The matrices were analyzed by TGA, SEM, XDR, DSC, and FTIR. Thin plate spline interpolation method (TPSIM) was used to predict the swelling of the matrices generating three‐dimensional data fitted, showing the influence of time and concentration variables on both fluids absorption. Polyhydroxybutyrate/chitosan samples containing 60 wt % (weight percent) of chitosan formed a porous structure as they were submitted to arnica loading, and the obtained device was able to deliver arnica in physiological medium. Thus, the produced matrices have a strong potential to perform both as scaffolds and DDS © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47838.