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MGF‐Ct24E‐modified piperazine polymer: A balance of antimicrobial activity and cytotoxicity
Author(s) -
Zhang Maolan,
Zeng Guoming,
Wang Yuanliang,
Zhao Zhiping
Publication year - 2019
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.47773
Subject(s) - piperazine , cytotoxicity , antibacterial activity , fourier transform infrared spectroscopy , antimicrobial , oligomer , polymer , nuclear chemistry , chemistry , materials science , polymer chemistry , organic chemistry , chemical engineering , biochemistry , bacteria , in vitro , engineering , genetics , biology
ABSTRACT A piperazine oligomer (PE) has been successfully synthesized via green and facile conditions. To obtain equivalent or better antimicrobial activity and smaller cytotoxicity, a mechano‐growth factor and its 24‐amino acid peptide analog corresponding to the unique C‐terminal E‐domain (MGF‐Ct24E) was introduced to the side chain of PE. Fourier transform infrared spectrometry (FTIR), elemental analysis, and amino acid analyzer (AAA) measurements showed that the MGF‐Ct24E‐modified piperazine polymer (PEM) was successfully prepared. The antibacterial activity and cytotoxicity of PEM were further investigated. Introduction of MGF‐Ct24E resulted in equivalent or improved antibacterial properties and reduced cytotoxicity compared to PE. The resulting material may replenish the current arsenal of synthetic polymeric antibacterial systems reported. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47773.