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Functionalizable composite nanoparticles as a dual magnetic resonance imaging/computed tomography contrast agent for medical imaging
Author(s) -
Illert Patrick,
Wängler Björn,
Wängler Carmen,
Zöllner Frank,
Uhrig Tanja,
Litau Shanna,
Pretze Marc,
Röder Thorsten
Publication year - 2019
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.47571
Subject(s) - magnetic resonance imaging , computed tomography , contrast (vision) , materials science , medical imaging , nanoparticle , composite number , nuclear magnetic resonance , magnetic nanoparticles , biomedical engineering , radiology , medicine , nanotechnology , computer science , composite material , physics , artificial intelligence
A dual contrast agent for computed tomography (CT) and magnetic resonance imaging (MRI) was synthesized via microemulsion polymerization. This contrast agent consists of Fe 3 O 4 particles ( d = 7 nm) with an iodine‐carrying nanopolymeric shell, with overall particle sizes ranging from 50 to 250 nm. 2‐Methacryloyloxyethyl(2,3,5‐triiodobenzoate) was used as the monomer. Sodium oleate was used as the surfactant and its amount was varied to control the overall particle size. The composite nanoparticles were mainly characterized via dynamic light scattering, with further analyses using transmission electron microscopy and atomic force microscopy. The particles provided a highly visible contrast in CT and MR images. A template for biomedical applications was created by adding a comonomer and the particles were further functionalized with the somatostatin analogue Tyr 3 ‐octreotate. The particles were tested for specific uptake into somatostatin receptor‐positive AR42J cells. The additional uptake of the functionalized particles was investigated. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47571.