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Synthesis and controlled release of curcumin‐β‐cyclodextrin inclusion complex from nanocomposite poly( N ‐isopropylacrylamide/sodium alginate) hydrogels
Author(s) -
KasapogluCalik Meltem,
Ozdemir Murat
Publication year - 2019
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.47554
Subject(s) - self healing hydrogels , swelling , curcumin , cyclodextrin , nuclear chemistry , nanocomposite , swelling capacity , poly(n isopropylacrylamide) , polymer chemistry , chemistry , acrylamide , controlled release , materials science , chemical engineering , copolymer , polymer , organic chemistry , composite material , nanotechnology , biochemistry , engineering
Inclusion complex of curcumin with β‐cyclodextrin (Cur‐β‐CD) was prepared using coprecipitation method. Stoichiometric ratio between curcumin and β‐cyclodextrin was found to be 1:2 with an association constant of 3.80 × 10 8 M −2 using Benesi–Hildebrand method. Inclusion complex formation was confirmed by FTIR and DSC analyses. Water solubility of curcumin increased from 0.00122 to 0.721 mg m L −1 with the inclusion complex formation. Release of the inclusion complex from the nanocomposite and conventional poly( N ‐isopropylacrylamide/sodium alginate hydrogels crosslinked by nanoclay and N,N′ ‐methylenebis(acrylamide) (BIS), respectively, were investigated in simulated gastrointestinal conditions. Swelling ratio and cumulative release were dependent on the hydrogel composition and pH. At pH = 1.2, hydrogels showed the lowest release ratio, but at pH = 6.8 highest swelling ratios were attained. The swelling ratio and cumulative release decreased with increasing the nanoclay content in nanocomposite hydrogels. On the contrary, as the ratio of BIS in the conventional hydrogels increased, the swelling ratio and cumulative release increased. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47554.