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Elastic antibacterial membranes comprising particulate laden fibers for wound healing applications
Author(s) -
Li Y.,
Zhang C.,
Zhu L.F.,
Ahmad Z.,
Li J.S.,
Chang M.W.
Publication year - 2019
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.47105
Subject(s) - membrane , ultimate tensile strength , materials science , thermoplastic polyurethane , electrospinning , composite material , polyurethane , tetracycline hydrochloride , wound care , wound dressing , elastomer , tetracycline , polymer , chemistry , surgery , medicine , biochemistry , antibiotics
Medicated skin care products are available in various forms; ranging from lotions and creams to bandages and membranes. In this study, antibacterial particulate laden fibrous membranes (FMs) were prepared via electrospraying of tetracycline hydrochloride‐loaded poly(ε‐caprolactone) particles alongside electrospinning of thermoplastic polyurethane (TPU) fibers, through which both mechanical and biological aspects of a complete membrane system can be achieved. Random (R) and ordered (P and V) patterns of TPU FMs were afforded using a rotating collector. Water contact angle and bacterial inhibition zone tests were performed to assess suitability of the system specifically for wound care. Stress–strain and in vitro drug release tests were performed to assess suitability of newly developed systems specifically for hybrid membranes (HMs). The highest tensile strength (32.1 ± 4.9 MPa) with elasticity (104.2 ± 6.0%) and the most sustained release rate indicate HMs (P) are potentially suitable materials for wound‐care applications. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47105.