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A facile method for fabricating nano/microfibrous three‐dimensional scaffold with hierarchically porous to enhance cell infiltration
Author(s) -
Li H.,
Ding Q.,
Chen X.,
Huang C.,
Jin X.,
Ke Q.
Publication year - 2019
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.47046
Subject(s) - scaffold , polycaprolactone , electrospinning , infiltration (hvac) , materials science , porosity , nanofiber , tissue engineering , cell adhesion , nanotechnology , composite material , biomedical engineering , adhesion , polymer , medicine
The integration of electrospinning and traditional needle punching technologies were demonstrated for fabricating a new three‐dimensional (3D) scaffold to enhance the cellular infiltration. This 3D scaffold combined the advantages of electrospun polycaprolactone (PCL) nanofibrous mats and carded chitosan microfibrous webs to construct hierarchically porous, which have three regions: the large pores (about 500 μm) on the nanofibrous mats generated by needle punching, could induce the massive cells infiltration into the inner scaffold; the small pores (30–200 μm) of the microfibrous webs allowed space for continuous cellular infiltration; and the inherent smaller pores of the nanofibrous mats (1–17 μm) which play a key role in providing a platforms for cell adhesion and proliferation. In addition, the 3D scaffold exhibited appropriate mechanical properties and significantly high initial cell attachment, proliferation, and infiltration, suggesting that its great potential in tissue engineering. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47046