One‐pot synthesis of palm oil‐based polyester polyol for production of biodegradable and biocompatible polyurethane

Palm oil‐based polyester polyol was synthesized by reacting epoxidized palm olein with malonic acid under a convenient one‐pot synthesis method. The optimum reaction time, temperature, and functionality molar ratio were determined. The optimal polyol consisted of hydroxyl and acid values of 98.19 and 1.44 mg KOH/g sample, 95% conversion of epoxides and M n of 5201 Da; and the chemical structure was elucidated by Fourier transform infrared , Carbon‐13 nuclear magnetic resonance (NMR), and 1 H‐NMR. The polyol was appeared as light‐yellowish liquid with cloud and pour points of 12 and 10 °C and reacted with isophorone diisocyanate to produce polyurethane with interconnected pores ranged 35–2165 μm, porosity ranged 89–90%, tensile strength ranged 59–78 kPa, and compression stress ranged 48–55 kPa. The polyurethanes showed 120–260% water‐uptake and controlled mass loss (1.6–15.3%) after 28 days of enzymatic degradation. PU 1 demonstrated slight cytotoxicity with cell proliferation and adhesion observed after 24 h incubation, demonstrated its potential as biomaterial for biomedical applications. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46861.