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Core–shell PVA /gelatin nanofibrous scaffolds using co‐solvent, aqueous electrospinning: Toward a green approach
Author(s) -
Sengor Mustafa,
Ozgun Alp,
Corapcioglu Gulcan,
Ipekoglu Mehmet,
Garipcan Bora,
Ersoy Nuri,
Altintas Sabri
Publication year - 2018
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.46582
Subject(s) - gelatin , electrospinning , vinyl alcohol , nanofiber , materials science , aqueous solution , chemical engineering , ultimate tensile strength , fourier transform infrared spectroscopy , solvent , composite material , polyvinyl alcohol , electrode , core (optical fiber) , polymer chemistry , polymer , chemistry , organic chemistry , engineering
Electrospinning (ES) of gelatin often requires cytotoxic organic solvents or acidic environments, which deteriorate cell recognition sites. In this study, aqueous, non‐toxic, co‐solvent ES was performed to obtain core–shell poly(vinyl alcohol) (PVA)/gelatin nanofiber scaffolds. Effects of the core/shell feed rate ratio (FRR) were investigated on a morphological and mechanical basis. PVA:gelatin ratio of 1:4 was the limiting ratio for specific voltage and electrode distance parameters to obtain uniform fibers. Core–shell bead‐free structures were obtained at 8% PVA and gelatin aqueous solutions. A mean diameter of 280 nm was obtained for 1:1 FRR at 15 kV and 15 cm of electrode distance. Crosslinking resulted in slight improvement in tensile strengths and severe decrease in ductility. Fourier transform infrared spectra revealed retention and improvement of stable secondary structures of gelatin after ES. The scaffolds almost degraded more than 60% in 14 days. Based on the results, present scaffolds hold great promise as suitable candidates for biomedical applications. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46582.