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Development of antimicrobial‐loaded polyurethane films for drug‐eluting catheters
Author(s) -
Barde Mehul,
Davis Montoia,
Rangari Shivani,
Mendis Hajeewaka C.,
De La Fuente Leonardo,
Auad Maria L.
Publication year - 2018
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.46467
Subject(s) - sulfathiazole , polyurethane , differential scanning calorimetry , fourier transform infrared spectroscopy , materials science , antimicrobial , thermal analysis , nuclear chemistry , chemical engineering , chemistry , composite material , organic chemistry , thermal , physics , meteorology , engineering , thermodynamics
To prepare antibacterial, polymeric catheters for preventing catheter‐induced infections, sulfathiazole was loaded into polyurethane by solubilizing with solvents and the resultant films were cast. Fourier transform infrared spectroscopy confirmed the presence of sulfathiazole in the drug‐loaded polyurethane films. The thermal and mechanical properties of the films were assessed using differential scanning calorimetry and dynamic mechanical analysis. The drug‐loaded films were immersed in constantly stirred, deionized water at 37 °C for in vitro drug release study. The experimental data obtained from the in vitro drug release study were fit into mathematical models. Antibacterial efficiency of released sulfathiazole was evaluated by Escherichia coli growth inhibition test. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46467.