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Fabrication of citric acid crosslinked β‐cyclodextrin/hydroxyethylcellulose hydrogel films for controlled delivery of poorly soluble drugs
Author(s) -
Sampatrao Ghorpade Vishwajeet,
Vyankatrao Yadav Adhikrao,
Jacky Dias Remeth,
Krishnat Mali Kailas
Publication year - 2018
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.46452
Subject(s) - swelling , thermogravimetric analysis , nuclear chemistry , citric acid , biocompatibility , chemistry , drug delivery , drug carrier , controlled release , titration , polymer chemistry , cyclodextrin , fourier transform infrared spectroscopy , cytotoxicity , self healing hydrogels , ultimate tensile strength , materials science , chemical engineering , organic chemistry , in vitro , nanotechnology , biochemistry , composite material , engineering
ABSTRACT β‐cyclodextrin grafted hydroxyethylcellulose (βCD‐ g ‐HEC) hydrogel films were prepared for the controlled release of poorly soluble model drug (ketoconazole) using citric acid as crosslinking agent. The active βCD and carboxyl content of the hydrogel films were determined by phenolphthalein assay and acid–base titration. The films were characterized by solid state 13 C NMR, ATR–FTIR, thermogravimetric analysis, and differential scanning calorimetric, and analyzed for tensile strength, swelling ratio, drug loading, release, hemocompatibility, in vitro cytotoxicity, and implantation test. An increase in the concentration of βCD in feed increased the active βCD content of the hydrogel films but reduced their extent of interpolymer crosslinking. The βCD‐ g ‐HEC hydrogel films with high active βCD content showed maximum drug loading whereas those with high crosslinking density were capable of controlling the drug release for long duration. Hemolysis assay and in vitro cytotoxicity study revealed the biocompatible nature of the hydrogel films whereas implantation test indicated their minimal inflammatory effect. From the overall results, βCD‐ g ‐HEC hydrogel films were found to be better alternative to the previously reported βCD‐HPMC and βCD‐CMC hydrogel films for enhanced loading and long‐term release, respectively, of the poorly soluble drugs. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46452.