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Polyurethane‐incorporated chitosan/alginate core–shell nano‐particles for controlled oral insulin delivery
Author(s) -
Bhattacharyya Aditi,
Nasim Farhat,
Mishra Roshnara,
Bharti Ram P.,
Kundu P.P.
Publication year - 2018
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.46365
Subject(s) - chitosan , fourier transform infrared spectroscopy , zeta potential , materials science , polyurethane , chemical engineering , bioavailability , swelling , mucoadhesion , coacervate , particle size , ionic strength , in vivo , nuclear chemistry , nanoparticle , chemistry , polymer chemistry , drug carrier , composite material , nanotechnology , drug delivery , organic chemistry , aqueous solution , bioinformatics , engineering , biology , microbiology and biotechnology
Chitosan (CS) and polyurethane‐chitosan (PU‐CS) nano‐particles (NPs) were prepared for the core formation by complex coacervation method whereas alginate (ALG) and PU‐ALG were crosslinked by ionic gelation method to form the protective shell‐layer over the core. Effects of PU incorporation either within the core or shell or both were investigated by different in vitro and in vivo parameters. Fourier transform infrared (FTIR) spectroscopy of different compositions of nano‐particles showed distinct characteristic peaks for CS, PU, and ALG, indicating their presence in variable ratios. Significance of polyurethane‐incorporated systems towards insulin encapsulation efficiency, swelling parameters, insulin release, and in vivo pharmacological effect were also studied. Particle sizes, zeta potential, morphological analysis, mucoadhesion study, and in vivo acute toxicity studies of these core–shell nano‐particles were also performed. Bioavailability of insulin ranged from 9.04% to 11.6% for polyurethane‐incorporated chitosan‐alginate core–shell nano‐particle formulations which was significantly higher than the insulin bioavailability of basic CS/ALG core–shell nano‐particle system. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46365.