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Fabrication of poly(lactic acid) nano‐ and microparticles using a nanomixer via nanoprecipitation or emulsion diffusion
Author(s) -
Hong Joung Sook,
Srivastava Devesh,
Lee Ilsoon
Publication year - 2018
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.46199
Subject(s) - mixing (physics) , materials science , diffusion , nanoparticle , emulsion , agglomerate , particle (ecology) , chemical engineering , fabrication , particle size , composite material , nanotechnology , thermodynamics , oceanography , physics , quantum mechanics , geology , engineering , medicine , alternative medicine , pathology
In order to investigate the influence of mixing flow condition on particle generation, poly(lactic acid) (PLA) particles were fabricated at different mixing velocities (10–50 m s −1 ) using a nanomixer through either the nanoprecipitation or the emulsion diffusion method. With a nanomixer (Couette–Taylor mixing geometry modified with cavitations), particles became smaller as the mixing velocity increased as long as the temperature was kept below the glass transition temperature ( T g ) of PLA. Even in the emulsion diffusion method, it led to the formation of PLA nanoparticles in a short emulsification time (∼1 min) and the mean diameter was less than 100 nm with deviation less than 10% (100 nm ± 10%). However, at high mixing velocity, the particle size was rapidly increased which was enhanced as mixing time increased. Dissipation rapidly increased the temperature inside the mixer above T g of PLA, which caused smaller particles to agglomerate to form larger micron‐sized particles. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46199.