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Cover Image, Volume 135, Issue 9
Publication year - 2018
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/app.46080
Subject(s) - micelle , copolymer , ethylene glycol , amphiphile , peg ratio , polymer chemistry , materials science , polymer science , polymer , chemistry , chemical engineering , organic chemistry , aqueous solution , engineering , business , finance
In a paper by Suming Li and colleagues, poly(e‐caprolactone)‐poly(ethylene glycol) (PCL‐PEG) and poly(ecaprolactone/glycolide)‐poly(ethylene glycol) (P(CL/GA)‐PEG) diblock copolymers were synthesized as potential drug carriers. Self‐assembly of the resulting amphiphilic copolymers yielded spherical or wormlike micelles, depending on the copolymer composition and the hydrophobic block length. Worm‐like micelles were exclusively obtained for PCL‐PEG, whereas spherical micelles were obtained for P(CL/GA)‐ PEG copolymers because introduction of glycolide disrupted the chain structure. Encapsulation of paclitaxel was realized in the core of micelles with high drug loading. Prolonged drug release was observed, showing that these micelles could be promising for applications as drug carriers. (DOI: 10.1002/app.45732 )